Does Vitamin D Help With Allergies
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Vitamin D and Microbiota: Is There a Link with Allergies?
by 1,2,* 
, 1,2 , 1,2 , 1,2 , 1,2 and 3
1
Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
2
Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy
3
School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: George P. Studzinski
Received: 18 March 2021 / Revised: 11 April 2021 / Accepted: 19 April 2021 / Published: 20 April 2021
Abstract
There is increasing recognition of the importance of both the microbiome and vitamin D in states of health and disease. Microbiome studies have already demonstrated unique microbial patterns in systemic autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. Dysbiosis also seems to be associated with allergies, in particular asthma, atopic dermatitis, and food allergy. Even though the effect of vitamin D supplementation on these pathologies is still unknown, vitamin D deficiency deeply influences the microbiome by altering the microbiome composition and the integrity of the gut epithelial barrier. It also influences the immune system mainly through the vitamin D receptor (VDR). In this review, we summarize the influence of the microbiome and vitamin D on the immune system with a particular focus on allergic diseases and we discuss the necessity of further studies on the use of probiotics and of a correct intake of vitamin D. View Full-Text
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style
Murdaca, G.; Gerosa, A.; Paladin, F.; Petrocchi, L.; Banchero, S.; Gangemi, S. Vitamin D and Microbiota: Is There a Link with Allergies? Int. J. Mol. Sci. 2021, 22, 4288. https://doi.org/10.3390/ijms22084288
AMA Style
Murdaca G, Gerosa A, Paladin F, Petrocchi L, Banchero S, Gangemi S. Vitamin D and Microbiota: Is There a Link with Allergies? International Journal of Molecular Sciences. 2021; 22(8):4288. https://doi.org/10.3390/ijms22084288
Chicago/Turabian Style
Murdaca, Giuseppe, Alessandra Gerosa, Francesca Paladin, Lorena Petrocchi, Sara Banchero, and Sebastiano Gangemi. 2021. "Vitamin D and Microbiota: Is There a Link with Allergies?" International Journal of Molecular Sciences 22, no. 8: 4288. https://doi.org/10.3390/ijms22084288
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Author Biographies
Associate Professor of Internal Medicine M.D., cum laude, University of Genova Allergology and Clinical Immunology, University of Genova PhD in Sciences and Space Engineering, University of Genova
Does Vitamin D Help With Allergies
Source: https://www.mdpi.com/1422-0067/22/8/4288
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